Sodium stibogluconate
From The Cure For The Needy
Contents |
Sodium Stibogluconate (Pentostam)
Effective Against
Leishmaniasis. It is only available for administration by injection.
Pentavalent antimony (Sb) in differential complex formation with gluconic acid with leishmanicidal and potential antineoplastic activities. The Sb moiety of sodium stibogluconate (SSG) may inhibit protein tyrosine phophorylases (PTPases) by covalently modifying sulfhydryl groups in PTPase cysteine residues, resulting in specific inactivation of SH2 domain-containing tyrosine phosphatases-1 and -2 (SHP-1 and SHP-2), PTPases which negatively regulate interferon (IFN) signaling; enhancement of IFN-induced Stat1 tyrosine phosphorylation; and induction of cellular protein tyrosine phosphorylation. SSG in combination with IFN-alpha may synergize to overcome tumor cell resistance to IFN-alpha-mediated apoptosis.
Cost
From Sigma-Aldrich: 501 USD (500mg)
Reported Route of Synthesis
Reaction of D-gluconic acid with HSb(OH)6 (Hexahydroxoantimonic acid) in the presence of NaOH affords the anhydrous form of the title compound (I). (1)
Vardnayan, R. Drugs for treating protozoan infections. Synthesis of essential drugs, Ruben Vardanya, Elsevier, Tucson, Arizona , 2006, 559
Cost of Starting Materials and Reagents:
D-Gluconic acid sodium salt from Sigma-Aldrich: 15.5 USD (500g)
Antimony Acid must be freshly precipitated