Mycobutin
From The Cure For The Needy
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Mycobutin (Rifabutin)
Effective Against
Tuberculosis. It is a bacterial antibiotic drug.
Rifabutin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
Cost
From Sigma-Aldrich: 65 USD (5mg) or 260 USD (25mg)
Reported Route of Synthesis
By reaction of 3-amino-4-deoxo-4-iminorifamycin S (I) with N-(2-methylpropyl)-4-piperidone (II) in methylene chloride.
Drugs Fut 1985, 10(5): 405
Marsili, L.; Rossetti, V.; Pasqualucci, C. (Archifar Laboratori Chimico Farmacologici SpA); Rifamycin compounds. BE 0870570; DE 2825445; FR 2426690; GB 1603127; JP 8007203; NL 7806659
Cost of Intermediates:
Rifamycin SV sodium salt from Sigma-Aldrich: 255.50 USD (5g)
Rifamycin SV sodium salt from MP Biomedicals: 216.25 USD (5g)
1-(2-Methylpropyl)-4-piperidone from Sigma-Aldrich: 104 USD (25G)