Leishmaniasis

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Contents

Leishmaniasis

Background

Leishmaniasis is a disease caused by protozoan parasites and is transmitted by the bite of certain species of sand fly. There are four forms of Leishmaniasis:

Cutaneous leishmaniasis - the most common form which causes a sore at the bite site, which heal in a few months to a year, leaving an unpleasant looking scar. This form can progress to any of the other three forms.
Visceral leishmaniasis - the most serious form and potentially fatal if untreated. In this form, the parasites have migrated to the vital internal organs.
Diffuse cutaneous leishmaniasis - this form produces widespread skin lesions which resemble leprosy and is particularly difficult to treat.
Mucocutaneous leishmaniasis - commences with skin ulcers which spread, causing tissue damage particularly to the nose and mouth

Parasite resistance is the main obstacle in finding effective treatment.

Current Treatments

Miltefosine


Sodium Stibogluconate


Paromomycin Sulfate

Further Reading

wikipedia:Leishmaniasis
Wikipedia Entry on Leishmaniasis

CDC Fact Sheet
Centers for Disease Control and Prevention Fact Sheet and other information

WHO-Leishmaniasis
Information from the World Health Organization on Leishmaniasis

WHO-TDR-Lesihmaniasis
The Tropical Disease Research and Training Division of WHO's information

TropIKA: Leishmaniasis
TDR's TropIKA.net (Tropical Disease Research to foster Innovation and Knowledge Application) contains many resources, such as journal articles, related to tropical diseases

DPDx - Leishmaniasis
CDC's Division of Parasitic Diseases - information on the life cycle of the causal agent