Iodoquinol
From The Cure For The Needy
Contents |
Iodoquinol (Diioodohydroxyquinoline, Diodoquin, Diquinol, Yodoquinol, Yodoxin)
Effective Against
Iodoquinol is an antiprotozoal medication (used to fight off infections from protozoa).
"All but the most severe cases of Amoebiasis can be treated with short cycles of medication. Abscesses throughout the body are first treated, using Metronidazole or a related drug, for 5-10 days. As abscesses cause most symptoms, treatment should show near-immediate increases in health including solid/bloodless stool, increase in appetite, and decrease in liver swelling. Metronidazole is only given to patients who present with severe illness. Both asymptomatic and symptomatic (after Metronidazole cycle) patients are given a second antibiotic such as Iodoquinol for 10-20 days to clear the remaining E. histolytica in the intestine and colon to prevent recurrence of abscesses. "
Study of Metronidazole
A succinct paper on Amebiasis and drugs used to treat it, focusing on Metronidazole, by a Rice University student
Cost
To consumers: Consumer cost is 86 USD for 60 (650mg) tablets. This translates to 1.43 USD per tablet.
North Drug Store
From Sigma-Aldrich: 36.20 USD (100g)
Reported Routes of Synthesis
Skraup reaction between 2-aminophenol (I) and glycerol (II) by heating with sulphuric acid and nitrobenzene, affords the 8-hydroxyquinoline (III) (1), which then undergoes iodination either with KI/KIO3 or HCl, I2·H2O to afford the title compound (1).
Greenstein, J.P. On a relation between the dissociation constants of substituted aliphatic acids and the distance between the dissociating and the substituted groups. J Am Chem Soc, 1936, 58(7): 1314
Vardnayan, R and Hruby, V. Synthesis of Essential Drugs. Elsevier:2006. pg. 573
Cost of Starting Materials and Selected Reagents:
Starting Material 2-aminophenol from Sigma-Aldrich: 13 USD (1 g)
Glycerol from Sigma-Aldrich: 33.8 USD (100 mL)
Sulfuric acid from Sigma-Aldrich: 67.2 USD (100 mL)
Nitrobenzene from Sigma-Aldrich: 12.4 USD (1 mL)
Potassium iodide from Sigma-Aldrich: 80.3 USD (100 g)
Potassium iodate from Sigma-Aldrich: 45.6 USD (5 g)